49ers Injury Updates: Ricky Pearsall Out, George Kittle Returns vs Falcons | NFL Week 15 (2025)

Here’s a bold statement: the San Francisco 49ers’ injury report just got a whole lot more interesting. But here’s where it gets controversial—while some key players are sidelined, others are making a surprising return, leaving fans and analysts alike scratching their heads. Let’s break it down.

The 49ers have officially ruled out quarterback Brock Purdy due to a toe injury and wide receiver Ricky Pearsall with a knee issue. This means Mac Jones is stepping in for his fifth start as Purdy’s replacement. Jones, who was limited in Wednesday’s practice with knee and oblique injuries, bounced back to full participation in the final two practices of the week. Interestingly, he doesn’t carry an injury designation, which raises the question: Is he truly 100%, or are the 49ers taking a calculated risk?

Now, for the good news: tight end George Kittle is ready to return after recovering from a hamstring injury. The team will activate him from injured reserve on Saturday, and he’s expected to play without any snap limitations against the Falcons. And this is the part most people miss—Kittle’s return could be a game-changer for the offense, especially with his ability to create mismatches and open up opportunities for other players.

Defensive tackle Kevin Givens, who’s been dealing with a pectoral injury, is also likely to return from injured reserve. Coach Kyle Shanahan confirmed, ‘George is playing, and Kevin most likely is.’ However, not everyone is so fortunate. Defensive end Yetur Gross-Matos is out with knee and hamstring issues, while cornerback Renardo Green (neck) and cornerback Upton Stout (shoulder) are listed as questionable. Could these absences weaken the defense at a critical moment?

Here’s a thought-provoking question for you: With Kittle’s return and Jones under center, are the 49ers setting themselves up for a strong finish, or are they risking further injuries by pushing players back too soon? Let us know your take in the comments—we’d love to hear your perspective!

49ers Injury Updates: Ricky Pearsall Out, George Kittle Returns vs Falcons | NFL Week 15 (2025)
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